                         SEQUENCE LISTING

<110>  The Brigham & Women's Hospital, Inc.
 
<120>  HYDROXAMATE INHIBITORS OF INSULIN-DEGRADING ENZYME AND USES 
       THEREOF

<130>  L0619.70009WO00

<150>  US 60/934587
<151>  2007-06-13

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (3)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  biotin-label

<400>  1

Met Gly Xaa Xaa Xaa Xaa Tyr Lys Pro Glu Lys Lys 
1               5                   10          


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Tyr Lys Pro Glu 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Phe Arg Trp Glu 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2NAP, beta-D-2-naphthylalanine, D-amino acid, hydroxamic 
       acid moiety

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  D-amino acid, acetyl group

<400>  4

Xaa Arg Tyr Glu 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2Nap, beta-D-2-naphthylalanine, hydroxamic acid moiety, 
       D-amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Bpa, benzophenylalanine, D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  EDANS-label

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  PEG-biotin-label, acetyl group

<400>  5

Xaa Arg Xaa Glu Glu 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2Nap, beta-D-2-naphthylalanine, D-amino acid, hydroxamic 
       acid moiety

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-amino acid,

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Bpa, benzophenylalanine, D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  PEG-biotin-label

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  EDANS-label, acetyl group

<400>  6

Xaa Arg Xaa Glu Glu 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  2Nap, beta-D-2-naphthylalanine, D-amino acid, hydroxamic 
       acid moiety

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Bpa, benzophenylalanine, D-amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  EDANS-label

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  PEG-biotin-label, acetyl group

<400>  7

Xaa Xaa Tyr Glu Glu 
1               5   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Abz, ortho-aminobenzoic acid-label

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Dnp, dinitrophenol-label

<400>  8

Gly Gly Phe Leu Arg Lys Val Gly Gln 
1               5                   


